Axiom™ - ტესტ-სისტემა მაღალი სიზუსტით აზიური პოპულაციის სამედიცინო კვლევისთვის, 96-იანი ფორმატი

Catalog number: 905423

Description:

The Axiom Asia Precision Medicine Research Array (PMRA) is a comprehensive imputation-aware genotyping array with more than 750,000 markers. The high-value content on the array is associated with both common and rare diseases for clinical research and disease association studies in East and South Asian populations. This array kit includes the 1x96-format array plate, as well as an Axiom 2.0 Reagent Kit and Axiom GeneTitan Consumables Kit.

The Asia PMRA is ideal for longitudinal cohort studies in precision medicine initiatives, bio-banking, translational research, direct-to-consumer applications, and clinical trials in drug discovery. Markers on the array were selected for the highest genomic coverage from 1000Genomes Project Phase III. Additional gene variants were chosen from broadly referenced public databases, including ClinVar, NHGRI-GWAS catalog, CPIC, PharmaGKB, and PharmaADME. A full description of the array is available in the content flyer.

Highlights:

• Genome-wide association studies (GWAS) imputation module of >540,000 markers from South and East Asian populations

• Broad coverage of common and rare variants associated with human health

• Minimum order size is one kit consisting of one 96-array plate, associated Axiom reagents, and GeneTitan MC consumables sufficient for 96 samples

• The array can be customized with 50,000 markers without affecting the imputation accuracy, or it can be fully customizable as required

Coverage:

• Genome-wide association study (GWAS) variants

• Evidence-based markers of potential clinical relevance (pharmacogenomics, ClinVar, ACMG, exclusive markers)

• Immune-related markers (human leukocyte antigen, killer immunoglobulin-like receptors, autoimmune and inflammatory)

• Functional variants (loss of function, expression quantitative trait loci, nonsynonymous variants, lung phenotypes)

• Disease-related variants (Alzheimer’s disease, cardiometabolic, neurological disorders, diabetes, cancer variants, cardiac variants, other rare variants)

• Tracking-related variants for tracking purposes (fingerprint and sample tracking , mitochondrial, Y chromosome)

Specifications: